(Oh dear Celestia...) Twilight ponynapping the mane 6, cutting off their skin. Making fake ponies of them to be better フレンズ after they had a bad fight. Then using the new mane 6 to every night kill a ポニー (in a gorey way) from Ponyville and so on.
Twilight could be interesting. I can see her going insane like in Lesson Zero, only this time X10. または maybe Fluttershy, it could have something to do with her animals.