What is the saddest scene in an anime/manga?

In FMA when Maes Hughes died.

ok , i understand that light needed to kill L（デスノート） so he could become " GOD " または sth , ugh , but its very mean to makeTHAT " creepy - twisted " SMILE when L（デスノート） died , i just wanna slap him ><

When Yoite died~
I was so~ extremely, sad~
i cried for hours.....and even now...just thinking about it...makes..me...saaad~ D':
I recently bought vol. 9 and 10 of Nabari no ou. i didnt actually think about which volumes i bought at that time, i saw Yoite at the front cover and.... yea~
so when i got back at the hotel, i decided; Lets read Nabari no ou, here, where its lots of ppl! ( i was in the lobby :P) then, i red vol. 9 and thought...hmm.....something doesnt feel right~
then...i read vol. 10.....and.. Yoite... died.....And i sat there, with lots of ppl around me, and was like; DONT CRY~ DONT CRY~ FOR GODS SAKE! DONT CRY~ (It didnt work though) so i turned away from all those ppl and cried...quietly.......( i hope no one noticed.. :P )

and btw~ that picture has nothing to do with his death :)

Ushio's death ! :(
From Clannad After Story

Nagisa's death

The ending of Cowboy Bebop (which I saw on Toonami last night).

I'm not going to spoil it for anyone, but I will say one thing: it managed to make me cry. And it takes a lot for an アニメ to make me cry.

When Kanade Tachibana graduates and leaves Otonashi Yuzuru behind... I cried for a month
(.>,<.)

kusaka and akizuki's death i cried for about an 時 after i watched/read it

This scene. This freaking scene. No matter how many times I watch it, I can't get through it without crying.

The Ending to Bokura Ga Ita , it left me depressed..T.T
and Misty's Good bye song:
link

Code Geass R2 ending

I could could name so many Lust-sans,Envy-kun's,Alexander and Nina's (also being turned into a chimera によって her own father), Lieutenant Colonel Hughes' passing from FMA/FMA Brotherhood,Mr.Kaiba trying to Save Mokuba but ended up being turned to stone によって Noa also when Mr.Kaiba tried to duel Peggy but ロスト his soul in attempt to get Mokuba's back,also hearing Peggy's past with his lover Cynthia in Yu-Gi-Oh,mostly ever part of AnoHana was sad for me,L-sama's passing in Death Note was very sad,Ushi-chan and Nagi-san's passing in Clannad + After Story was sad I felt really bad for Tomoya-kun..yes my 一覧 can go on I cry at almost everything I find to be sad.

Ichigo and Rukia's farewell...

Dammit! I cried and my ハート, 心 was broken in a hundred pieces...Just によって staring at their faces, their words, their feelings...
Studio Pierrot made a great work with the 音楽 and the アニメーション was flawless. Never ever seen anything so touching and heartbreaking.