somehow I just think that they wud be interesting... xD

I really don't like any of these couples, but I think Callie and Owen could me not-so-horrible together... ;)

Alex 'n Arizona are the best... xDDD

LOL yeah I agree with Merder_4eva
the scene where Mark tried to hit on her and failed, Cristina's obviously the hard-to-get type and Mark's ego is too big. they would make a very interesting couple!! x]

i would be extremely happy

Or Derek/Izzie,Mer/Mark

OMG the thought of Denny&Cristina is extremly disturbing xD

Oh yeah, bow chicka bow bow.

Mer and Mark <33 Hell yes! That coul be awesome ;D
Dirty mistress club ;D

Agree that Mark&Cristina would be interesting, but I can't really imagine it.

And Derek/Izzie, what a glory. Like Elina said. Very happy.

Denny&Cristina, can't really imagine. BUT HOT PIC<3

My choose is Meredith&Mark, can't really explain why..

I also think that Izzie and Hunt would have been interesting!

mer/mark and der/iz would be cool even though i would never change lexzie or merder!!!

it would be really interesting

I think they would be cute! lol!

i had love them together:D

EW, Derek/Izzie is the most disgusting thought ever! EW!
A/A would be intressting. xD

maybe Alex&Arizona or even Denny&Cristina, I´ve never thought about either one of them
but I´ve chosen these two, I think it would be really funny at some point and it´s unimaginable how that could work, but I actually think it would :D but that thing with a "Change" - like Derek&Addie vz. Mark&Mer is just fiasco...