"All changes, even the most longed for, have their melancholy; for what we leave behind us is a part of ourselves; we must die to one life before we can enter another."
Wincest! Well, story is simple. Sam found out that Dean is unfaithful to him. He broke up but Dean did not want to let him go and so he had to live with the consequences and the fact that Sam never will be his lover again...