probally not well because most monsters are immune to missels and guns and some monsters are even immune to nuclear bombs for example godzilla
said someone who was a godzilla expert and 1 of the only 1954 survivors in godzilla 1985 "no matter what happens Godzilla will live" now what was happening was that Russia launched a nuke to kill godzilla and the americans launched another 1 to intercept it so it would destroy the city even more. the radiation would just feed godzilla and explosions dont affect most monsters like godzilla mothra or king ghidorah